Impact of Manganese on and Transfer across the Blood-brain and Blood-csf Barrier in Vitro
نویسندگان
چکیده
Background: Modes of neurotoxic action after Mnoverexposure are not fully understood. Results: The blood-CSF barrier showed higher Mnsensitivity and active Mn-transport properties. Conclusion: The blood-CSF barrier might be the major route for Mn into the brain. Significance: Deeper insight in the impact of Mn on and its transfer across brain barrier systems might help to prevent irreversible neurological damage.
منابع مشابه
Impact of manganese on and transfer across blood-brain and blood-cerebrospinal fluid barrier in vitro.
Manganese occupational and dietary overexposure has been shown to result in specific clinical central nervous system syndromes, which are similar to those observed in Parkinson disease. To date, modes of neurotoxic action of Mn are still to be elucidated but are thought to be strongly related to Mn accumulation in brain and oxidative stress. However, the pathway and the exact process of Mn upta...
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